The simplex optimization method has been
used successfully a great number of times to optimize high-performance liquid
chromatography (HPLC) methods.
Primary control variables (factors) in the optimization of liquid chromatography (LC)
methods are the different components of the mobile phase determining acidity, solvent
strength, etc.
Application note 4: Optimization of a HPLC method.
Back to the description of the MultiSimplex software
