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Application Notes on Experimental Design and Optimization

Applications examples.

Application notes is a series of short articles on different practical optimization issues. Your suggestions are highly appreciated.

Application note 1. Optimization strategies.

A discussion of different approaches to experimental optimization. Compares the sequential simplex and simultaneous methods.

 

Application note 2. Mixture optimization.

A discussion about mixture optimization with the sequential simplex method. Practical advice on procedure in MultiSimplex.

Application note 3. Optimization of a gas chromatographic method.

In routine chromatographic separations, it is of crucial importance to keep the total run time short, without jeopardizing necessary chromatographic resolution. This application note shows an example on how this can be achieved with the MultiSimplex software.

 

Application note 4. Optimization of a HPLC method.

In many pharmaceutical applications of high-performance liquid chromatography (HPLC), it is of outmost importance to find optimal separation conditions for different products. This application note shows how this can be achieved with the MultiSimplex software.

 

Application note 5. Optimization of a CHP plant.

An environmental charge on emissions of nitrogen oxides (NO_x) has created a strong incentive for optimization of many combustion plants in Sweden. We have successfully used sequential simplex optimization as a tool in this work. This application note is a brief description of one such project.

 

Application note 6. Optimization of an extrusion process in the food industry

There are numerous reports on the successful application of simplex optimization to food product and process development. This application note give an example from an extrusion process.