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Yes, definitely. MultiSimplex is only a tool and of no value at all if you do not apply your own skill and technical know-how. MultiSimplex is however a very powerful optimization tool in combination with technical skills.
I want to produce "good quality", but how do I specify the optimization objectives? How can I optimize, when the specifications do not allow any change in conditions? Can the system be too complicated for MultiSimplex? The process is not stable, how is it possible to optimize? Is MultiSimplex necessary if there is only one important variable affecting the response? Is there any industrial experience with these methods? How does the MultiSimplex methods compare with ordinary statistical methods? Can MultiSimplex solve any optimization problem?
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